Genetic knockout of porcine GGTA1 or CMAH/GGTA1 is associated with the emergence of neo-glycans.
Lucrezia MorticelliCharlotte RossdamSamanta CajicDietmar BöthigMikhail MagdeiSugat Ratna TuladharBjoern PetersenKonrad FischerErdmann RappSotirios KorossisAxel HaverichAngelika SchniekeAndres HilfikerFalk F R BüttnerAndres HilfikerPublished in: Xenotransplantation (2023)
Genetic deletion of GGTA1 or GGTA1/CMAH removes specific epitopes providing a more human-like glycosylation pattern, but at the same time changes distribution and levels of other porcine glycans that are potentially immunogenic.