GTSP1 expression in non-smoker and non-drinker patients with squamous cell carcinoma of the head and neck.
Pamela de Oliveira SoaresPatrícia Maluf CuryRossana Verónica Mendoza LópezCláudio Roberto CerneaErika Erina FukuyamaDavid Livingstone Alves FigueiredoFrancisco Gorgonio da NobregaOtavio Alberto CurioniFabio Daumas NunesRaquel Ajub MoysesMaria Lúcia Bueno Garcianull nullPublished in: PloS one (2017)
This study showed that GTSP1 was expressed in tumors of HNSCC patients regardless of smoking, drinking or HPV infection status. The difference in GTSP1 expression in non-tumor margins between the two groups may have been due to two possible reasons. First, elevated GTSP1 expression in SD patients might be the result of activation of GTSP1 in response to exposure to carcinogens. Second, alternatively, impairment in the detoxifying system of GTSP1, as observed by the reduced expression of GTSP1, might make patients susceptible to carcinogens other than tobacco and alcohol, which may be the underlying mechanism of carcinogenesis in the absence of risk factors.