Oct4 transcriptionally regulates the expression of long non-coding RNAs NEAT1 and MALAT1 to promote lung cancer progression.
Jayu JenYen-An TangYing-Hung LuChe-Chung LinWu-Wei LaiYing-Jan WangPublished in: Molecular cancer (2017)
Our study reveals a novel mechanism by which Oct4 transcriptionally activates NEAT1 via promoter and MALAT1 via enhancer binding to promote cell proliferation and motility, and led to lung tumorigenesis and poor prognosis.