Promoter expression of HERV-K (HML-2) provirus-derived sequences is related to LTR sequence variation and polymorphic transcription factor binding sites.

Meagan MontesionZachary H WilliamsRavi P SubramanianCharlotte KuperwasserJohn M Coffin

Published in: Retrovirology (2018)

These data suggest that stage-specific transcription factors at least partly contribute to LTR promoter activity during transformation and that, in some cases, transcription factor binding site polymorphisms may be responsible for the differential HML-2 expression often seen between individuals.

Keyphrases

transcription factor
poor prognosis
dna binding
genome wide identification
binding protein
dna methylation
gene expression
electronic health record
big data
deep learning
amino acid