Bacteroides uniformis combined with fiber amplifies metabolic and immune benefits in obese mice.
Inmaculada López-AlmelaMarina Romaní-PérezClara Bullich-VilarrubiasAlfonso Benítez-PaézEva M Gómez Del PulgarRubén FrancésGerhard LiebischYolanda SanzPublished in: Gut microbes (2022)
Gut microbiota represents a therapeutic target for obesity. We hypothesize that B. uniformis CECT 7771 combined with wheat bran extract (WBE), its preferred carbon source, may exert superior anti-obesity effects. We performed a 17-week intervention in diet-induced obese mice receiving either B. uniformis, WBE, or their combination to identify interactions and independent actions on metabolism and immunity. B. uniformis combined with WBE was the most effective intervention, curbing weight gain and adiposity, while exerting more modest effects separately. The combination restored insulin-dependent metabolic routes in fat and liver, although the bacterium was the primary driver for improving whole-body glucose disposal. Moreover, B. uniformis-combined with WBE caused the highest increases in butyrate and restored the proportion of induced intraepithelial lymphocytes and type-3 innate lymphoid cells in the intestinal epithelium. Thus, strengthening the first line of immune defense against unhealthy diets and associated dysbiosis in the intestine. This intervention also attenuated the altered IL22 signaling and liver inflammation. Our study shows opportunities for employing B. uniformis, combined with WBE, to aid in the treatment of obesity.
Keyphrases
- weight gain
- weight loss
- insulin resistance
- type diabetes
- randomized controlled trial
- metabolic syndrome
- body mass index
- birth weight
- oxidative stress
- adipose tissue
- high fat diet induced
- induced apoptosis
- skeletal muscle
- cell death
- diabetic rats
- peripheral blood
- endoplasmic reticulum stress
- anti inflammatory
- placebo controlled
- drug induced
- pi k akt