Reduction of De Novo Lipogenesis Mediates Beneficial Effects of Isoenergetic Diets on Fatty Liver: Mechanistic Insights from the MEDEA Randomized Clinical Trial.
Giuseppina CostabileGiuseppe Della PepaDominic SalamoneDelia LuongoDaniele NaviglioValentina BrancatoCarlo CavaliereMarco SalvatorePaola CiprianoMarilena VitaleAlessandra CorradoAngela Albarosa RivelleseGiovanni AnnuzziLutgarda BozzettoPublished in: Nutrients (2022)
A diet rich in multiple beneficial dietary components (fiber, polyphenols, MUFAs, PUFAs, and other antioxidants) compared to a diet rich only in MUFAs further reduces liver fat accumulation through the inhibition of DNL. Registered under ClinicalTrials.gov no. NCT03380416.