Antimicrobial strategy for targeted elimination of different microbes, including bacterial, fungal and viral pathogens.
Makoto MitsunagaKimihiro ItoTakashi NishimuraHironori MiyataKei MiyakawaTakeshi MoritaAkihide RyoHisataka KobayashiYoshimitsu MizunoeTadayuki IwasePublished in: Communications biology (2022)
The continuous emergence of microbial pathogens for which there are no effective antimicrobials threatens global health, necessitating novel antimicrobial approaches. Here, we present a targeted antimicrobial strategy that can be applied to various microbial pathogens. A photoimmuno-conjugate composed of an antibody against the target pathogen and a photoplastic phthalocyanine-derivative probe that generates photo-induced mechanical stress was developed based on photoimmuno-technology. This strategy, named as photoimmuno-antimicrobial strategy (PIAS), eliminates targeted pathogens, regardless of the target species or drug-resistance status. Specifically, PIAS acts on a broad range of microbes, including the bacterial pathogen Staphylococcus aureus, fungal pathogen Candida albicans, including their drug-resistant strains, and viral pathogen SARS-CoV-2, the causative agent of COVID-19. Furthermore, PIAS protects mice from fatal infections without damaging the non-targeted host microbiota and tissues. This study may contribute to the development of next-generation anti-infective therapies.
Keyphrases
- candida albicans
- staphylococcus aureus
- sars cov
- drug resistant
- biofilm formation
- cancer therapy
- gram negative
- multidrug resistant
- global health
- antimicrobial resistance
- microbial community
- respiratory syndrome coronavirus
- acinetobacter baumannii
- coronavirus disease
- escherichia coli
- drug delivery
- public health
- methicillin resistant staphylococcus aureus
- adipose tissue
- oxidative stress
- photodynamic therapy
- quantum dots
- skeletal muscle
- stress induced
- pseudomonas aeruginosa