Genetic variants and expression changes in urgency urinary incontinence: A systematic review.
Wilke M PostAlejandra M Ruiz-ZapataHilde GrensRob B M de VriesGeert PoelmansMarieke J H CoenenDick A W JanssenJohn P F A HeesakkersEgbert OosterwijkKirsten B KluiversPublished in: Neurourology and urodynamics (2020)
The collective evidence showed the involvement of two molecular mechanisms (signal transduction and inflammation) and NGF in UUI, enhancing our understanding of the pathophysiology of UUI. Unfortunately, the risk of bias was medium-high to high for most studies and the value of many observations remains unclear. Future studies should focus on elucidating how deficits in the two identified molecular mechanisms contribute to UUI and should avoid bias.