Gene Expression Signature of Acquired Chemoresistance in Neuroblastoma Cells.
Mohamed JemaàWondossen SimeYasmin AbassiVito Alessandro LasorsaJulie Bonne KøhlerMartin MichaelisJindrich CinatlMario CapassoRamin MassoumiPublished in: International journal of molecular sciences (2020)
Drug resistance of childhood cancer neuroblastoma is a serious clinical problem. Patients with relapsed disease have a poor prognosis despite intense treatment. In the present study, we aimed to identify chemoresistance gene expression signatures in vincristine resistant neuroblastoma cells. We found that vincristine-resistant neuroblastoma cells formed larger clones and survived under reduced serum conditions as compared with non-resistant parental cells. To identify the possible mechanisms underlying vincristine resistance in neuroblastoma cells, we investigated the expression profiles of genes known to be involved in cancer drug resistance. This specific gene expression patterns could predict the behavior of a tumor in response to chemotherapy and for predicting the prognosis of high-risk neuroblastoma patients. Our signature could help chemoresistant neuroblastoma patients in avoiding useless and harmful chemotherapy cycles.
Keyphrases
- gene expression
- induced apoptosis
- cell cycle arrest
- poor prognosis
- end stage renal disease
- dna methylation
- endoplasmic reticulum stress
- newly diagnosed
- ejection fraction
- chronic kidney disease
- squamous cell carcinoma
- cell death
- prognostic factors
- genome wide
- transcription factor
- young adults
- diffuse large b cell lymphoma
- lymph node metastasis
- multiple myeloma
- combination therapy