Reliability of histologic assessment for NAFLD and development of an expanded NAFLD activity score.
Rish K PaiVipul JairathMalcolm HoganGuangyong ZouOyedele A AdeyiQuentin Mark AnsteeBashar A AqelCynthia BehlingElizabeth J CareyAndrew D CloustonKathleen E CoreyBrian G FeaganDavid E KleinerChristopher MaStefanie C McFarlaneMazen NoureddinVlad RatziuMark A ValasekZobair M YounossiStephen A HarrisonStephen CaldwellPublished in: Hepatology (Baltimore, Md.) (2022)
After extensive preparation among a group of experienced pathologists, we demonstrated improved reliability of multiple existing histologic NAFLD indices and fibrosis staging systems. Hepatocyte ballooning and MDBs most strongly correlated with disease activity and were used for the expanded NAS. Further validation including evaluation of responsiveness is required.