A threshold concentration of FSH is needed during IVM of ex vivo collected human oocytes.

Jesús CadenasDmitry NikiforovSusanne Elisabeth PorsLenin Arturo ZunigaYu WakimotoZeinab GhezelayaghLinn Salto MamsenStine Gry KristensenClaus Yding Andersen

Published in: Journal of assisted reproduction and genetics (2021)

FSH improved oocyte nuclear maturation at concentrations above 70 IU/L suggesting a threshold for FSH during IVM of ex vivo collected human oocytes from small antral follicles. Moreover, current results for the first time highlight that FSH function in vitro is mediated via cumulus cells by downregulating FSHR and upregulating LHCGR, which was also observed when the immature oocytes progressed in meiosis from the GV to the MII stage.

Keyphrases

endothelial cells
induced pluripotent stem cells
induced apoptosis
pluripotent stem cells
cell proliferation
signaling pathway
oxidative stress