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Nrf2 Regulates the Expression of CYP2D6 by Inhibiting the Activity of Krüppel-Like Factor 9 (KLF9).

Ferbian Milas SiswantoRita Dewi FirmasyahMaria Dara Novi HandayaniAmi OguroSusumu Imaoka
Published in: Current drug metabolism (2023)
Our work revealed the inhibitory role of Nrf2 in regulating CYP2D6 expression. Moreover, Nrf2- dependent regulation of CYP2D6 can be used as a prognostic factor and therapeutic strategy in PD and liver cancer.
Keyphrases
  • prognostic factors
  • poor prognosis
  • oxidative stress
  • signaling pathway
  • transcription factor