Nrf2 Regulates the Expression of CYP2D6 by Inhibiting the Activity of Krüppel-Like Factor 9 (KLF9).

Ferbian Milas SiswantoRita Dewi FirmasyahMaria Dara Novi HandayaniAmi OguroSusumu Imaoka

Published in: Current drug metabolism (2023)

Our work revealed the inhibitory role of Nrf2 in regulating CYP2D6 expression. Moreover, Nrf2- dependent regulation of CYP2D6 can be used as a prognostic factor and therapeutic strategy in PD and liver cancer.

Keyphrases

prognostic factors
poor prognosis
oxidative stress
signaling pathway
transcription factor