ROR2 has a protective role in melanoma by inhibiting Akt activity, cell-cycle progression, and proliferation.

María Victoria CastroGastón Alexis BarberoMaría Belén VillanuevaLuca GrumolatoJérémie NsengimanaJulia Newton-BishopEdith IllescasMaría Josefina QuezadaPablo Lopez-Bergami

Published in: Journal of biomedical science (2021)

We conclude that the expression of ROR2 slows down the growth of primary tumors and contributes to prolonging melanoma survival. Our results demonstrate that ROR2 has a far more complex role than originally described.

Keyphrases

cell cycle
signaling pathway
cell proliferation
poor prognosis
skin cancer