Evaluation of DNA methylation status of toll-like receptors 2 and 4 promoters in Behcet's disease.

Sousan KolahiNadereh RashtchizadehAida Malek MahdaviJafar FarhadiAlireza KhabbaziEbrahim SakhiniaNeda BahavarniaMohammad Jahed Farajzadeh PolsangiZohreh BabalooMehrdad A Estiar

Published in: The journal of gene medicine (2020)

Our preliminary findings suggest that the hypomethylation of TLR4 gene may be involved in the pathogenesis of BD via increasing TLR4 expression.

Keyphrases

dna methylation
toll like receptor
inflammatory response
genome wide
immune response
poor prognosis
copy number
gene expression
nuclear factor
binding protein