Initiating tocilizumab, with or without methotrexate, compared with starting methotrexate with prednisone within step-up treatment strategies in early rheumatoid arthritis: an indirect comparison of effectiveness and safety of the U-Act-Early and CAMERA-II treat-to-target trials.

Maxime M A VerhoevenMarjolein Jh de HairJanneke TekstraJohannes Wj BijlsmaJacob M van LaarAttila Pethoe-SchrammMichelle Ea BormEvert-Jan Ter BorgSuzanne P Linn-RaskerXavier M TeitsmaFloris Pjg LafeberJohannes Wg JacobsPaco Mj Welsing

Published in: Annals of the rheumatic diseases (2019)

In patients with early RA, although TCZ-based strategies resulted in better DAS28 and remission rates compared with MTX+pred, at least part of these effects may be due to a specific effect of TCZ on APRs.

Keyphrases

rheumatoid arthritis
disease activity
high dose
systemic lupus erythematosus
rheumatoid arthritis patients
ankylosing spondylitis
juvenile idiopathic arthritis
low dose
machine learning
high resolution
idiopathic pulmonary fibrosis
systemic sclerosis