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Visible-Light Photocatalytic Decarboxylative Alkyl Radical Addition Cascade for Synthesis of Benzazepine Derivatives.

Yu ZhaoJia-Rong ChenWen-Jing Xiao
Published in: Organic letters (2017)
A visible-light photocatalytic decarboxylative alkyl radical addition cascade reaction of acrylamide-tethered styrenes for the synthesis of benzazepine derivatives is described. This protocol features broad substrate scope, excellent functional group tolerance, and mild reaction conditions, affording the seven-membered rings in good yields. This method was also applied for efficient grafting of the benzazepine scaffold into the pharmaceutically active ursolic acid scaffold.
Keyphrases
  • visible light
  • tissue engineering
  • randomized controlled trial
  • structure activity relationship
  • electron transfer
  • reduced graphene oxide