Independent endothelial functions of PIEZO1 and TRPV4 in hepatic portal vein and predominance of PIEZO1 in mechanical and osmotic stress.
Naima EndeshEulashini Chuntharpursat-BonCharlotte RevillNadira Y YuldashevaT Simon FutersGregory ParsonageNeil E HumphreysAntony D AdamsonLara C MorleyRichard M CubbonK Raj PrasadRichard FosterLaeticia LichtensteinDavid J BeechPublished in: Liver international : official journal of the International Association for the Study of the Liver (2023)
The portal vein contains independently functioning PIEZO1 channels and TRPV4 channels in the endothelium, the pharmacological activation of which leads to opposing effects of vessel relaxation (PIEZO1) and contraction (TRPV4). In mechanical and osmotic strain, the PIEZO1 mechanism dominates. Modulators of these channels could present important new opportunities for manipulating liver perfusion and regeneration in disease and surgical procedures.