D-dopachrome tautomerase drives astroglial inflammation via NF-κB signaling following spinal cord injury.

Hui LiBingqiang HeXingyuan ZhangHuifei HaoTing YangChunshuai SunHonghua SongYingjie WangYue ZhouZhenjie ZhuYuming HuYongjun Wang

Published in: Cell & bioscience (2022)

Collectively, D-DT is a novel proinflammatory mediator of astrocytes following SCI. Insights of its cell-specific expression and relevant proinflammatory mechanisms will provide clues for the control of CNS inflammation.

Keyphrases

spinal cord injury
oxidative stress
poor prognosis
signaling pathway
spinal cord
single cell
neuropathic pain
cell therapy
blood brain barrier
pi k akt
nuclear factor
cell proliferation
stem cells
mesenchymal stem cells
bone marrow