Impact of chronic use of heat-not-burn cigarettes on oxidative stress, endothelial dysfunction and platelet activation: the SUR-VAPES Chronic Study.
Lorenzo LoffredoRoberto CarnevaleSimona BattagliaRoberta MartiStefano PizzoloSimona BartimocciaCristina NocellaVittoria CammisottoSebastiano SciarrettaIsotta ChimentiElena De FalcoElena CavarrettaMariangela PeruzziAntonino MarulloFabio MiraldiFrancesco VioliAndrea MorelliGiuseppe Biondi ZoccaiGiacomo FratiPublished in: Thorax (2021)
Tobacco habit still represents the leading preventable cause of morbidity and mortality worldwide. Heat-not-burn cigarettes (HNBCs) are considered as an alternative to traditional combustion cigarettes (TCCs) due to the lack of combustion and the absence of combustion-related specific toxicants. The aim of this observational study was to assess the effect of HNBC on endothelial function, oxidative stress and platelet activation in chronic adult TCC smokers and HNBC users. The results showed that both HNBC and TCC display an adverse phenotype in terms of endothelial function, oxidative stress and platelet activation. Future randomised studies are strongly warranted to confirm these data.
Keyphrases
- oxidative stress
- smoking cessation
- particulate matter
- dna damage
- clinical trial
- ischemia reperfusion injury
- diabetic rats
- sewage sludge
- heat stress
- municipal solid waste
- induced apoptosis
- randomized controlled trial
- emergency department
- young adults
- air pollution
- adverse drug
- heat shock
- deep learning
- study protocol
- signaling pathway
- heavy metals