Methylation of the AIM2 gene: An epigenetic mediator of PTSD-related inflammation and neuropathology plasma biomarkers.

Sage E HawnZoe NealeErika J WolfXiang ZhaoMeghan PierceDana Fein-SchafferWilliam MilbergRegina McGlincheyMark LogueMark W Miller

Published in: Depression and anxiety (2022)

Given that AIM2 methylation mediated the association between PTSD symptoms and multiple inflammatory and neuropathology markers, our results suggest that AIM2 methylation may offer clinical utility for indexing risk for adverse health outcomes associated with these peripheral indices of inflammation and neuropathology. Results also suggest a possible shared etiology underlying the frequent co-occurrence of inflammation and neuropathology.

Keyphrases

oxidative stress
genome wide
dna methylation
gene expression
posttraumatic stress disorder
social support
emergency department
depressive symptoms
physical activity
transcription factor
sleep quality