Plasma adiponectin levels and risk of heart failure, atrial fibrillation, aortic valve stenosis, and myocardial infarction: large scale observational and Mendelian randomization evidence.
Maria Booth NielsenYunus ÇolakMarianne BennAmy MasonStephen BurgessBørge Grønne NordestgaardPublished in: Cardiovascular research (2023)
Observationally, elevated plasma adiponectin was associated with increased risk of heart failure, atrial fibrillation, aortic valve stenosis, and myocardial infarction. However, genetic evidence did not support causality for these associations.
Keyphrases
- aortic valve
- heart failure
- atrial fibrillation
- transcatheter aortic valve replacement
- transcatheter aortic valve implantation
- aortic valve replacement
- aortic stenosis
- left ventricular
- metabolic syndrome
- left atrial
- catheter ablation
- oral anticoagulants
- insulin resistance
- cardiac resynchronization therapy
- left atrial appendage
- acute heart failure
- direct oral anticoagulants
- genome wide
- percutaneous coronary intervention
- cross sectional
- gene expression
- skeletal muscle
- copy number
- dna methylation
- coronary artery disease
- mitral valve
- venous thromboembolism