An online GPCR structure analysis platform.

Albert Jelke KooistraChristian MunkAlexander Sebastian Hauser David E Gloriam

Published in: Nature structural & molecular biology (2021)

We present an online, interactive platform for comparative analysis of all available G-protein coupled receptor (GPCR) structures while correlating to functional data. The comprehensive platform encompasses structure similarity, secondary structure, protein backbone packing and movement, residue-residue contact networks, amino acid properties and prospective design of experimental mutagenesis studies. This lets any researcher tap the potential of sophisticated structural analyses enabling a plethora of basic and applied receptor research studies.

Keyphrases

amino acid
high throughput
case control
electronic health record
high resolution
big data
risk assessment
mass spectrometry
climate change
small molecule
deep learning