Significant inter- and intra-laboratory variation in grading of ductal carcinoma in situ of the breast: a nationwide study of 4901 patients in the Netherlands.
Carmen van DooijeweertPaul J van DiestStefan M WillemsChantal C H J KuijpersLucy I H OverbeekIvette A G DeckersPublished in: Breast cancer research and treatment (2018)
In this cohort of 4901 patients, we observed substantial inter- and intra-laboratory variation in DCIS grading, not explained by differences in case-mix. Therefore, there is an urgent need for nationwide standardization of grading practices, especially since the future management of DCIS may alter significantly depending on histologic grade.