Overexpression of keap1 may induce oxidative stress injury in hucMSCs by down-regulating IKKβ expression and inhibiting NF-κB pathway activation. This implies the importance of keap1 in hucMSCs and it may be a potential gene for genetic modification of hucMSCs.
Keyphrases
- umbilical cord
- mesenchymal stem cells
- oxidative stress
- protein protein
- signaling pathway
- genome wide
- endothelial cells
- bone marrow
- dna damage
- copy number
- poor prognosis
- ischemia reperfusion injury
- diabetic rats
- cell therapy
- cell proliferation
- small molecule
- transcription factor
- stem cells
- long non coding rna
- climate change
- genome wide identification