Genome-wide association meta-analysis of fish and EPA+DHA consumption in 17 US and European cohorts.
Dariush MozaffarianHassan S DashtiMary K WojczynskiAudrey Y ChuJennifer A NettletonSatu MännistöKati KristianssonMägi ReedikJari LahtiDenise K HoustonMarilyn C CornelisFrank J A van RooijMaria DimitriouStavroula KanoniVera MikkiläLyn M SteffenMarcia C de Oliveira OttoLu QiBruce PsatyLuc DjousseJerome I RotterKennet HaraldMarkus PerolaHarri RissanenAntti JulaFischer KristaEvelin MihailovMary F FeitosaJulius S NgwaLuting XuePaul F JacquesMia-Maria PeräläAarno PalotieYongmei LiuNike A NallsLuigi FerrucciDena HernandezAni ManichaikulMichael Y TsaiJessica C Kiefte-de JongAlbert HofmanAndré G UitterlindenLoukianos RallidisPaul M RidkerLynda M RoseJulie E BuringTerho LehtimäkiMika KähönenJorma ViikariRozenn LemaitreVeikko SalomaaPaul KnektAndres MetspaluIngrid B BoreckiL Adrienne CupplesJohan G ErikssonStephen B KritchevskyStefania BandinelliDavid SiscovickOscar H FrancoPanos DeloukasGeorge DedoussisDaniel I ChasmanOlli RaitakariToshiko TanakaPublished in: PloS one (2017)
These novel findings suggest that non-genetic personal and environmental factors are principal determinants of the remarkable variation in fish consumption, representing modifiable targets for increasing intakes among all individuals. Genes underlying the signal at rs72838923 and mechanisms for the association warrant further investigation.