Characterization of interaction between blood coagulation factor VIII and LRP1 suggests dynamic binding by alternating complex contacts.
Haarin ChunJames H KurasawaPhilip OlivaresEkaterina S MarakasovaSvetlana A ShestopalGabriela U HassinkElena KarnaukhovaMary MiglioriniJuliet O ObiAlly K SmithPatrick L WintrodePrasannavenkatesh DuraiKeunwan ParkDaniel J DeredgeDudley K StricklandAndrey G SarafanovPublished in: Journal of thrombosis and haemostasis : JTH (2022)
FVIII and LRP1 interact via formation of multiple complex contacts involving both canonical and non-canonical binding combinations. We propose that FVIII-LRP1 interaction occurs via switching such alternative binding combinations in a dynamic mode, and that this mechanism is relevant to other ligand interactions of the low-density lipoprotein receptor family members including LRP1.