Unveiling inflammatory and prehypertrophic cell populations as key contributors to knee cartilage degeneration in osteoarthritis using multi-omics data integration.
Yue FanXuzhao BianXiaogao MengLei LiLaiyi FuYanan ZhangLong WangYan ZhangDalong GaoXiong GuoMikko Juhani LammiGuangdun PengShiquan SunPublished in: Annals of the rheumatic diseases (2024)
Our results highlight InfC, preHTC, preFC and HTC as potential cell populations to target for therapy. Also, we conclude that profiling of those cell populations in patients might be used to stratify patient populations for defining cohorts for clinical trials and precision medicine.
Keyphrases
- single cell
- clinical trial
- cell therapy
- end stage renal disease
- rheumatoid arthritis
- total knee arthroplasty
- chronic kidney disease
- randomized controlled trial
- oxidative stress
- genetic diversity
- knee osteoarthritis
- stem cells
- machine learning
- electronic health record
- risk assessment
- big data
- bone marrow
- human health
- deep learning