Molecular Imaging of Chimeric Antigen Receptor T Cells by ICOS-ImmunoPET.
Federico SimonettaIsrat S AlamJuliane K LohmeyerBita SahafZinaida GoodWeiyu ChenZunyu XiaoToshihito HiraiLukas SchellerPujan EngelsOphir VermeshElise RobinsonTom HaywoodAtaya SathirachindaJason Thanh LeeMeena B MalipatlollaLiora M SchultzJay Y SpiegelDavid Bernard MiklosCrystal L MackallSanjiv Sam GambhirRobert S NegrinPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)
This study highlights the potential of ICOS-immunoPET imaging for monitoring of CAR T-cell therapy, a strategy readily applicable to both commercially available and investigational CAR T cells.See related commentary by Volpe et al., p. 911.