Antibacterial Polyketides Isolated from the Marine-Derived Fungus Fusarium solani 8388.

Seven new polyketides named fusarisolins F-K ( 1 - 6 ) and fusarin I ( 7 ) were isolated from the marine-derived fungus Fusarium solani 8388, together with the known anhydrojavanicin ( 8 ), 5-deoxybostry coidin ( 9 ), and scytalol A ( 10 ). Their structures were established by comprehensive spectroscopic data analyses, and by comparison of the 1 H and 13 C NMR data with those reported in literature. Fusarisolin F ( 1 ) contained both a dichlorobenzene group and an ethylene oxide unit, which was rare in nature. In the bioassays, fusarisolin I ( 4 ), fusarisolin J ( 5 ), and 5-deoxybostry coidin ( 9 ) exhibited obvious antibacterial activities against methicillin-resistant Staphylococcus aureus n315 with MIC values of 3, 3, and 6 μg/mL, respectively. Fusarisolin H ( 3 ) and fusarisolin J ( 5 ) showed inhibitory effects against methicillin-resistant Staphylococcus aureus NCTC 10442 with the same MIC value of 6 μg/mL. With the exception of 5 , all other compounds did not show or showed weak cytotoxicities against HeLa, A549, and KB cells; while fusarisolin J ( 5 ) demonstrated moderate cytotoxicities against the three human cancer cell lines with CC 50 values between 9.21 and 14.02 μM.