An exhausted phenotype of TH 2 cells is primed by allergen exposure, but not reinforced by allergen-specific immunotherapy.
Shu-Hung WangUlrich M ZisslerMaren BuettnerSonja HeineAlexander HeldnerSebastian KotzLisa PechtoldJosephine KauMirjam PlaschkeJulia T UllmannFerdinand GuerthMadlen OelsnerFrancesca AlessandriniSimon BlankAdam M ChakerCarsten B Schmidt-WeberConstanze A JakwerthPublished in: Allergy (2021)
This study shows that allergen exposure promotes CTLA-4 and PD-1 expression on TH 2 cells and that the dynamic change in frequencies of exhausted TH 2 cells exhibits a differential pattern during the up-dosing versus the maintenance phases of AIT.