Pancreatic beta cell autophagy is impaired in type 1 diabetes.
Charanya MuralidharanAbass M ContehMichelle R MarascoJustin J CrowderJeroen KuipersPascal de BoerAmelia K LinnemannPublished in: Diabetologia (2021)
We provide evidence of islet macroautophagy/crinophagy impairment in human type 1 diabetes. We also document accumulation of telolysosomes with peripheral nitrogen in beta cells of autoantibody-positive donors, demonstrating altered lysosome content that may be associated with lysosome dysfunction before clinical hyperglycaemia. Similar macroautophagy impairments are present in the NOD mouse model of type 1 diabetes.