Optical Fiber-Enabled In Situ Photocatalytic Hydrogen Generation for Infiltrating Tumor Therapy in Brain.

In addition to repressing proliferation, inhibiting infiltration of tumor cells is an important strategy to improve the treatments of malignant tumors. Herein, a photocatalyst (pCNMC@Pt) is designed by sequentially assembling manganese dioxide, chlorin e6, and platinum (Pt) nanoparticles onto protonated graphitic carbon nitride. With the help of Z-scheme structure and near-infrared (NIR) photosensitizer, pCNMC@Pt is capable of responding to NIR light to generate large amounts of hydrogen (H 2 ). Taking lactic acid in tumor microenvironment as sacrificial reagent, H 2 therapy initiated by the NIR photocatalyst remarkably impedes the growth of glioblastoma (GBM). More importantly, it is found that H 2 can suppress the stemness of gliomas stem cells, curbing both proliferation and infiltration of GBM. Furthermore, since pCNMC@Pt and light source is precisely co-localized through a self-built loading and illumination system, GBM in mouse brains can be efficiently treated, providing an alternative gas therapy approach to cure infiltrating tumors. This article is protected by copyright. All rights reserved.