Comparative single-cell RNA-sequencing profiling of BMP4-treated primary glioma cultures reveals therapeutic markers.

Iris S C VerploeghAndrea ConidiRutger W W BrouwerHayri E BalciogluPanagiotis KarrasSamira MakhzamiAnne KorporaalJean-Christophe MarineMartine LamfersWilfred F J Van IJckenSieger LeenstraDanny Huylebroeck

Published in: Neuro-oncology (2022)

The changes in composition of patient-derived GBM cultures obtained after treatment with BMP4 correlate with treatment efficacy. OLIG1/2 expression can predict this efficacy, and upregulation of RPL27A and RPS27 are useful early-response markers.

Keyphrases

single cell
rna seq
poor prognosis
mesenchymal stem cells
bone regeneration
signaling pathway