circKCNN2 suppresses the recurrence of hepatocellular carcinoma at least partially via regulating miR-520c-3p/methyl-DNA-binding domain protein 2 axis.

Donghong LiuWenbin LiuXi ChenJianhua YinLongteng MaMei LiuXinyu ZhouLinfeng XianPeng LiXiaojie TanJun ZhaoYong LiaoGuang-Wen Cao

Published in: Clinical and translational medicine (2022)

circKCNN2, transcriptionally repressed by NFYA, suppresses HCC recurrence via the miR-520c-3p/MBD2 axis. Inherent level of circKCNN2 in HCC cells predisposes anti-tumor effect of lenvatinib possibly because both circKCNN2 and lenvatinib repress the expression of FGFR4. circKCNN2 may be a promising predictive biomarker and therapeutic agent for HCC recurrence.

Keyphrases

dna binding
long non coding rna
cell proliferation
free survival
poor prognosis
signaling pathway
induced apoptosis
long noncoding rna
transcription factor
binding protein
protein protein
cell death