Lipid-lowering therapy in patients with coronary artery disease undergoing percutaneous coronary interventions in Italy: an expert opinion paper of Interventional Cardiology Working Group of Italian Society of Cardiology.
Paolo CalabròCarmen SpaccarotellaArturo CesaroGiuseppe AndòRaffaele PiccoloSalvatore De RosaMarco ZimarinoMassimo ManconeFelice GragnanoElisabetta MoscarellaSaverio MuscoliFrancesco RomeoFrancesco BarillàPasquale Perrone FilardiCiro IndolfiGiampaolo Niccolinull nullPublished in: Journal of cardiovascular medicine (Hagerstown, Md.) (2023)
After percutaneous coronary interventions (PCIs), patients remain at high risk of developing recurrent cardiovascular events. Despite advances in interventional cardiology, the correct management of residual low-density lipoprotein cholesterol (LDL-C) risk continues to be crucial for improving long-term outcomes after PCI. However, several observational studies have demonstrated suboptimal LDL-C control, poor adherence to statin therapy, and underutilization of high-intensity statins, ezetimibe, and proprotein convertase subtilisin/kexin type 9 inhibitors in real-world clinical practice despite a strong endorsement from international guidelines. Recent studies have shown that early intensive lipid-lowering therapy stabilizes atheromatous plaque and increases fibrous cap thickness in patients with acute coronary syndrome. This finding emphasizes the importance of achieving therapeutic targets by establishing an effective treatment as early as possible. The aim of this expert opinion paper of the Interventional Cardiology Working Group of the Italian Society of Cardiology is to discuss the management of lipid-lowering therapy in patients undergoing PCIs according to Italian reimbursement policies and regulations, with a particular focus on the discharge phase.
Keyphrases
- coronary artery disease
- clinical practice
- cardiovascular events
- high intensity
- cardiovascular disease
- cardiac surgery
- patients undergoing
- minimally invasive
- stem cells
- acute myocardial infarction
- percutaneous coronary intervention
- acute coronary syndrome
- thoracic surgery
- ejection fraction
- public health
- newly diagnosed
- physical activity
- bone marrow
- prognostic factors
- fatty acid
- metabolic syndrome
- body composition
- st elevation myocardial infarction
- type diabetes
- end stage renal disease
- replacement therapy
- skeletal muscle
- peritoneal dialysis
- cell therapy
- aortic stenosis
- optical coherence tomography
- weight loss
- st segment elevation myocardial infarction
- ultrasound guided