A new ex vivo human model of osteoarthritis cartilage calcification.

Elodie FaureJulien WegrzynIlaria BernabeiGuillaume FalgayracNicolas BertheaumeTristan PascartThomas HugleNathalie BussoSonia Nasi

Published in: Rheumatology (Oxford, England) (2024)

We have described a new ex vivo human model of cartilage calcification that can summurize the triad of events seen during osteoarthritis progression, i.e. calcification, inflammation, and cartilage degradation. This model will allow the identification of new anti-calcification compounds.

Keyphrases

endothelial cells
chronic kidney disease
rheumatoid arthritis
extracellular matrix
pluripotent stem cells