Production of Terretonin N and Butyrolactone I by Thermophilic Aspergillus terreus TM8 Promoted Apoptosis and Cell Death in Human Prostate and Ovarian Cancer Cells.
Ayman A GhfarMohammad Magdy El-MetwallyMohamed ShaabanSami A GabrNada S GabrMarwa S M DiabAhmad AqelMohamed A HabilaWahidah H Al-QahtaniMohammad Y AlfaifiSerag Eldin I ElbehairiBayan Ahmed AlJumahPublished in: Molecules (Basel, Switzerland) (2021)
The anticancer activity of terretonin N (1) and butyrolactone I (2), obtained from the thermophilic fungus Aspergillus terreus TM8, was intensively studied against prostate adenocarcinoma (PC-3) and ovary adenocarcinoma (SKOV3) human cell lines. According to this study, both compounds showed potent cytotoxicity towards ovarian adenocarcinoma cells (SKOV3) with IC50 1.2 and 0.6 μg/mL, respectively. With respect to metastatic prostate cells (PC-3), the two compounds 1 and 2 showed a significantly promising cytotoxicity effect with IC50 of 7.4 and 4.5 μg/mL, respectively. The tested fungal metabolites showed higher rates of early and late apoptosis with little or no necrotic apoptotic pathway in all treated prostate adenocarcinoma (PC-3) and ovary adenocarcinoma (SKOV3) human cell lines, respectively. The results reported in this study confirmed the promising biological properties of terretonin N (1) and butyrolactone I (2) as anticancer agents via the induction of cellular apoptosis. However, further studies are needed to elucidate the molecular mechanism by which cellular apoptosis is induced in cancer cells.
Keyphrases
- cell cycle arrest
- cell death
- prostate cancer
- squamous cell carcinoma
- endothelial cells
- endoplasmic reticulum stress
- induced apoptosis
- pi k akt
- oxidative stress
- locally advanced
- benign prostatic hyperplasia
- induced pluripotent stem cells
- small cell lung cancer
- pluripotent stem cells
- high glucose
- anaerobic digestion
- cell proliferation