Ceruloplasmin and Coronary Heart Disease-A Systematic Review.
Antonio P Arenas de LarrivaLaura Limia-PérezJuan F Alcalá-DíazAlvaro AlonsoJosé López-MirandaJavier Delgado-ListaPublished in: Nutrients (2020)
Several studies indicate that oxidative stress might play a central role in the initiation and maintenance of cardiovascular diseases. It remains unclear whether ceruloplasmin acts as a passive marker of inflammation or as a causal mediator. To better understand the impact of ceruloplasmin blood levels on the risk of cardiovascular disease, and paying special attention to coronary heart disease, we conducted a search on the two most commonly used electronic databases (Medline via PubMed and EMBASE) to analyze current assessment using observational studies in the general adult population. Each study was quality rated using criteria developed by the US Preventive Services Task Force. Most of 18 eligible studies reviewed support a direct relationship between ceruloplasmin elevated levels and incidence of coronary heart disease. Our results highlight the importance of promoting clinical trials that determine the functions of ceruloplasmin as a mediator in the development of coronary heart disease and evaluate whether the treatment of elevated ceruloplasmin levels has a role in the prognosis or prevention of this condition.
Keyphrases
- cardiovascular disease
- oxidative stress
- clinical trial
- healthcare
- primary care
- type diabetes
- case control
- randomized controlled trial
- dna damage
- ischemia reperfusion injury
- machine learning
- quality improvement
- cardiovascular risk factors
- cardiovascular events
- signaling pathway
- induced apoptosis
- big data
- phase iii
- double blind