Optimised plasma sample preparation and LC-MS analysis to support large-scale proteomic analysis of clinical trial specimens: Application to the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) trial.
Matthew B O'RourkeAndrzej S JanuszewskiDavid R SullivanImre LengyelAlan J StewartSwati AryaRonald C MaSanjeev GalandeAnandwardhan A HardikarMugdha V JoglekarAnthony C KeechAlicia J JenkinsMark P MolloyPublished in: Proteomics. Clinical applications (2023)
A robust plasma handling and LC-MS proteomics workflow for abundant plasma proteins has been developed for large-scale biomarker studies that balance proteomic depth with time and resource costs.