C19MC amplification and expression of Lin28A and Olig2 in the classification of embryonal tumors of the central nervous system: A 14-year retrospective study from a tertiary care center.
Aruna NambirajanNiteeka GurungVaishali SuriChitra SarkarAmandeep KumarManmohan SinghMehar Chand SharmaPublished in: Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery (2020)
ETMR, C19MC-altered constitute less than 14% of CETs, with majority remaining uncharacterized as CET, NOS. Lin28A is 100% sensitive for the detection of C19MC amplification; however, its specificity is limited by its expression in ATRTs. Olig2 expression is seen only in a small subset of CET, NOS and is of limited diagnostic utility.