Chemotherapy drives tertiary lymphoid structures that correlate with ICI-responsive TCF1+CD8+ T cells in metastatic ovarian cancer.
Tereza LanickovaMichal HenslerLenka KasikovaSarka VosahlikovaArtemis AngelidouJosef PasulkaHannah GrieblerJana DrozenováKaterina MojzisovaAnn VankerckhovenJan LacoAleš RyškaPavel DundrRoman KocianDavid CibulaTomas BrtnickyPetr SkapaFrancis JacobMarek KovářIvan PraznovecIain A McNeishMichael Jiří HalaškaLukáš RobAn CoosemansSandra OrsulicLorenzo GalluzziRadek SpisekJitka FucikovaPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)
Altogether, our findings suggest that NACT promotes TLS formation and maturation in HGSOC lesions, de facto preserving an intratumoral ICI-sensitive T-cell phenotype. These observations emphasize the role of rational design, especially relative to the administration schedule, for clinical trials testing chemotherapy plus ICIs in patients with HGSOC.