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Comparative efficacy and tolerability of solifenacin 5 mg/day versus other oral antimuscarinic agents in overactive bladder: A systematic literature review and network meta-analysis.

Jameel NazirCon KelleherSamuel AballéaKhaled MamanZalmai HakimiColette MankowskiIsaac Odeyemi
Published in: Neurourology and urodynamics (2017)
This NMA suggests that the efficacy of solifenacin 5 mg/day is at least similar to other common antimuscarinics across the spectrum of OAB symptoms analyzed, and is more effective than tolterodine 4 mg/day in reducing incontinence and UUI episodes. Solifenacin 5 mg/day has a lower risk of dry mouth compared with several agents.
Keyphrases
  • systematic review
  • open label
  • randomized controlled trial
  • meta analyses
  • sleep quality
  • depressive symptoms
  • network analysis