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A phase 1 clinical trial of SP16, a first-in-class anti-inflammatory LRP1 agonist, in healthy volunteers.

George F WohlfordLeo F BuckleyDinesh KadariyaTaeshik ParkJuan Guido ChiabrandoSalvatore CarboneVirginia MihalickMatthew S HalquistAdam PearcyDana AustinCohava GelberAntonio AbbateBenjamin W Van Tassell
Published in: PloS one (2021)
A one-time treatment with SP16 for doses up to 0.2 mg/kg or 12 mg was safe in healthy volunteers.
Keyphrases
  • clinical trial
  • anti inflammatory
  • open label
  • randomized controlled trial
  • combination therapy
  • double blind
  • phase iii
  • replacement therapy
  • smoking cessation