Topiramate dosage optimization for effective antiseizure management via population pharmacokinetic modeling.

Seolah Lee Hyun Chul Kim Yoonhyuk Jang Han Sang Lee Seon-Jae Ahn Soon Tae Lee Keun Hwa Jung Kyung-Il ParkKi-Young JungJaeseong Oh Seung Hwan Lee Kyung-Sang Yu In-Jin Jang Soyoung Lee Kon Chu Sang Kun Lee

Published in: Annals of clinical and translational neurology (2023)

This study proposed an optimal therapeutic concentration for topiramate based on patients' responsiveness to the drug and the incidence of adverse effects. We recommended serum levels below 6.5 mg/L to mitigate the risk of ataxia-related side effects while dose elevation was found unnecessary for suboptimal responders, as the drug's effectiveness plateaus at minimal doses.

Keyphrases

end stage renal disease
newly diagnosed
ejection fraction
chronic kidney disease
randomized controlled trial
systematic review
peritoneal dialysis
prognostic factors
emergency department
drug induced
adverse drug
patient reported
electronic health record