Sortilin is associated with progranulin deficiency and autism-like behaviors in valproic acid-induced autism rats.

Ailing LiaoWenxia ZhengShali WangNashi WangYingbo LiDi ChenYan Wang

Published in: CNS neuroscience & therapeutics (2024)

Collectively, our findings highlight elevated sortilin levels in ASD rat brains, exacerbating dendrite impairment by affecting PGRN expression. PGRN supplementation and SORT1 knockdown hold potential as therapeutic strategies for ASD.

Keyphrases

autism spectrum disorder
intellectual disability
attention deficit hyperactivity disorder
poor prognosis
oxidative stress
replacement therapy
human health