A rapid α-synuclein seed assay of Parkinson's disease CSF panel shows high diagnostic accuracy.

Christina D OrrúThong C MaAndrew G HughsonBradley R GrovemanAnkit SrivastavaDouglas GalaskoRachel AngersPatrick DowneyKaren CrawfordSamantha J HuttenUn Jung KangByron Caughey

Published in: Annals of clinical and translational neurology (2020)

Our improved α-synuclein seed amplification assay dramatically reduces the time needed to diagnose Parkinson's disease while maintaining the high-performance standards associated with previous α-synuclein seed assays, supporting the clinical utility of this assay for Parkinson's disease diagnosis.

Keyphrases

high throughput
single cell
quantum dots
cerebrospinal fluid
nucleic acid