MicroRNA-21 Controls Circadian Regulation of Apoptosis in Atherosclerotic Lesions.
Andreas SchoberRichard Michael BlaySaffiyeh Saboor MalekiFarima ZahediAnja E WinklmaierMati Y KakarIsabelle M BaatschMengyu ZhuClaudia GeißlerAnja E FuscoAnna EberleinNan LiRemco T A MegensRamin BanafscheJörg KumbrinkChristian WeberMaliheh Nazari-JahantighPublished in: Circulation (2021)
Our findings suggest that the molecular clock in atherosclerotic lesions induces a diurnal rhythm of apoptosis regulated by circadian Mir21 expression in macrophages that is not matched by efferocytosis, thus increasing the size of the necrotic core.