Sulforaphane represses matrix-degrading proteases and protects cartilage from destruction in vitro and in vivo.

Rose K DavidsonOrla JuppRachel de FerrarsColin D KayKirsty L CulleyRosemary NortonClare DriscollTonia L VincentSimon T DonellYongping BaoIan M Clark

Published in: Arthritis and rheumatism (2014)

SFN inhibits the expression of key metalloproteinases implicated in osteoarthritis, independently of Nrf2, and blocks inflammation at the level of NF-κB to protect against cartilage destruction in vitro and in vivo.

Keyphrases

oxidative stress
extracellular matrix
poor prognosis
signaling pathway
rheumatoid arthritis
knee osteoarthritis
binding protein
pi k akt
immune response