Nephrectomy and high-salt diet inducing pulmonary hypertension and kidney damage by increasing Ang II concentration in rats.
Qian JiangQifeng YangChenting ZhangChi HouWei HongMin DuXiaoqian ShanXuanyi LiDansha ZhouDongmei WenYuanhui XiongKai YangZiying LinJingjing SongZhanjie MoHuazhuo FengYue XingXin FuChunli LiuFang PengLiling WuBing LiWenju LuJason X-J YuanJian WangYuqin ChenPublished in: Respiratory research (2024)
Our findings suggest that the development of pulmonary arterial hypertension in CKD-PH rats is likely a consequence of a combined effect: RAAS dysregulation, decreased ACE2 expression in pulmonary vascular endothelial cells, and metabolic disturbances.