Molecular Changes in Circulating microRNAs' Expression and Oxidative Stress in Adults with Mild Cognitive Impairment: A Biochemical and Molecular Study.
Hadeel A Al-RawafAhmad H AlghadirSami A GabrPublished in: Clinical interventions in aging (2021)
Circulating miR-124a, miR-483-5p, miR-142-3p, and miR-125b significantly associated with severe cognitive decline, cellular oxidative stress, and apoptosis in patients with MCI. Thus, it could be potential non-invasive biomarkers for the diagnosis of MCI with high diagnostic performance.
Keyphrases
- mild cognitive impairment
- cognitive decline
- oxidative stress
- diabetic rats
- dna damage
- ischemia reperfusion injury
- poor prognosis
- long non coding rna
- induced apoptosis
- cell proliferation
- endoplasmic reticulum stress
- long noncoding rna
- cell death
- risk assessment
- heat shock
- binding protein
- cell cycle arrest
- heat stress